Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

Design and Synthesis of 4-flurophthalimides as potential anticonvulsant agents

Objective(s): Anticonvulsant activity of phthalimide was discovered in 2000 by molecular hybridization of thalidomide and ameltolide. In our previous research we have reported some new 4-substituted derivatives of phthalimide with good activity against the tonic and clonic seizures Material and Methods: A series of novel 4-flurophthalimides that designed using bioisosteric replacement were synt...

synthesis and docking studies of new 4-oxo-1,3-thiazolidine derivatives as potential anticonvulsant agents

Synthesis of New Thiazole, Bithiazolidinone and Pyrano[2,3-d ]thiazole Derivatives as Potential Antimicrobial Agents

In an attempt to find a new class of antimicrobial agents, a series of thiazole derivatives containing furan moiety 3, 7, 8a,b, 10a-c and 12 were prepared via the reaction of 2-cyano-N-(furan-2-ylmethyl)acetamide (1) with phenyl isothiocyanate and α-halocarbonyl compounds. Also, many bithiazolidinone and pyranothiazole derivatives were synthesized through interaction of thiazolidinone 7 with ap...

STUDIES ON SPIROHETEROCYCLES : SYNTHESIS OF NEW SPIRO 4- THIAZOLIDINONES AS POSSIBLE BIODYNAMICS

Spiro-4- thiazolidinones have been synthesized by the cyclocondensation of phthalazinyl hydrazones with cyclic ketones and substituted mercapto acetic acids. Compounds were screened for their antibacterial, antifungal and antihypertensive activity. The combined elemental analyses and spectroscopic data prove the authenticity of the synthesized compounds